Keywords
Stercula oblonga
Organo-sulphur
Phenols
Hydrocarbons
How to Cite
Abstract
The stem-bark of sterculla oblonga, which is a rich lignocellulosic material, was analysed using GC-MS chromatography in other to identify the bioactive compounds present in the plant and deduce its possible therapeutic potentials. The pulverized plant sample was extracted by maceration for 48 hours using ethanol solvent, after solvent recovery, the crude extract was used for the GC-MS analysis. Results revealed the presence of 12 bioactive compounds namely: 1-(Butylsulfanyl)-2-ethoxyethane 4-methoxyphenol (mequinol), 2,6-dimethoxy-phenol (Syringol), 3,4,5-Trimethoxyphenol, 4,4,5,6-Tetramethyltetrahydro-1,3-oxazin-2-thione, n-Hexadecanoic acid (Palmitic acid), 1-Docosene, 14-methyl-8-hexadecen-1-ol, 1,19-Eicosadiene, Z-10-Tetradecen-1-ol acetate, 1-Nonadecene and Oleic Acid. These chemicals were further grouped into 5 viz organo-sulphur (2%), phenols (24%), alkaloids (2%), fatty acids/esters (22.18%) and hydrocarbons (8.66%). Because of the high percentage of phenolic compounds present, the ethanolic extract of stem-bark of Stercula oblonga could find useful therapeutic applications as antimicrobial, anti-cancer, anti-oxidant and anti-diabetic agents.
References
Lobo FC, Franco AR, Fernandes EM, Reis RL. An overview of the antimicrobial properties of lignocellulosic materials. Molecules. 2021 Mar 20;26(6):1749.
Ojo AO. An overview of lignocellulose and its biotechnological importance in high-value product production. Fermentation. 2023 Nov 20;9(11):990.
Cos P, Vlietinck AJ, Berghe DV, Maes L. Anti-infective potential of natural products: How to develop a stronger in vitro ‘proof-of-concept’. Journal of ethnopharmacology. 2006 Jul 19;106(3):290-302.
Nassr-Allah AA, Aboul-Enein AM, Aboul-Enein KM, Lightfoot DA, Cocchetto A, El-Shemy HA. Anti-cancer and anti-oxidant activity of some Egyptian medicinal plants. J Med Plants Res. 2009 Oct 1;3(10):799-808.
Gil MI, Tomás-Barberán FA, Hess-Pierce B, Kader AA. Antioxidant capacities, phenolic compounds, carotenoids, and vitamin C contents of nectarine, peach, and plum cultivars from California. Journal of agricultural and food chemistry. 2002 Aug 14;50(17):4976-82.
Sasidharan S, Chen Y, Saravanan D, Sundram KM, Latha LY. Extraction, isolation and characterization of bioactive compounds from plants’ extracts. African journal of traditional, complementary and alternative medicines. 2011;8(1).
Bosh AH. and Louppe D. Sterculia oblonga.in: (Louppe D, Oteng-Ainoako AA and Brin M. Plant Resource of Tropical Africa (PROTA), Wageningen, Netherlands. 2008.
Ezeonu CS, Ejikeme CM. Qualitative and quantitative determination of phytochemical contents of indigenous Nigerian softwoods. New journal of Science. 2016;2016(1):5601327.
Morah FN, Bisong EA. Chemical composition and testosterone level enhancing property of Sterculia oblonga leaf essential oil in male albino rats. Public Health. 2019;6(100024P16FM2019):100024P16FM2019.
Morah FN, Bisong EA. Chemical composition of Sterculia oblonga leaf petroleum spirit extract and its testosterone level enhancing property in male albino rats. International Journal of Chemical and Biochemical Sciences. 2021;19:89-93.
Shoaib S, Ansari MA, Ghazwani M, Hani U, Jamous YF, Alali Z, Wahab S, Ahmad W, Weir SA, Alomary MN, Yusuf N. Prospective epigenetic actions of organo-sulfur compounds against cancer: perspectives and molecular mechanisms. Cancers. 2023 Jan 23;15(3):697.
Abdelbasset WK, Elkholi SM, Ismail KA, AL-Ghamdi HS, Mironov S, Ridha HS, Maashi MS, Thangavelu L, Mahmudiono T, Mustafa YF. Mequinol-loaded carboxymethyl cellulose/chitosan electrospun wound dressing as a potential candidate to treat diabetic wounds. Cellulose. 2022 Sep;29(14):7863-81.
Almeida RS, Taccini MM, de Moura LF, Ceribelli UL, Brito JO, Gloria EM. Potential of pyroligneous extract of Eucalyptus wood as a preservative of cosmetic and sanitizing products. Waste and Biomass Valorization. 2019 May 1;10:1111-8.
Oramahi H, Yoshimura T, Rusmiyanto E, Kustiati K. Antifungal and antitermitic activities of vinegars from two biomass resources at different pyrolytic temperatures. Journal of Applied Biological Sciences. 2020 Apr 29;14(1):26-38.
Parmar VS, Gupta S, Bisht KS, Mukherjee S, Boll PM, Errington W. Synthesis and X-ray structure of 2-(3-methyl-2-butenyl)-3, 4, 5-trimethoxyphenol: a potent anti-invasive agent against solid tumours. Acta Chemica Scandinavica. 1996 Jun 1;50(6):558.
Verotta L, Dell'Agli M, Giolito A, Guerrini M, Cabalion P, Bosisio E. In vitro antiplasmodial activity of extracts of Tristaniopsis species and identification of the active constituents: Ellagic acid and 3, 4, 5-trimethoxyphenyl-(6 ‘-O-galloyl)-O-β-D-glucopyranoside. Journal of natural products. 2001 May 25;64(5):603-7.
Dardouk F, Arandi H, Makharzeh M. Extraction of Corn silk and its applications in healing and cosmetics’.Student project, 2019. An-Najah National University, Palestine.
Aparna V, Dileep KV, Mandal PK, Karthe P, Sadasivan C, Haridas M. Anti‐inflammatory property of n‐hexadecanoic acid: structural evidence and kinetic assessment. Chemical biology & drug design. 2012 Sep;80(3):434-9.
Ravi L, Krishnan K. Research article cytotoxic potential of N-hexadecanoic acid extracted from Kigelia pinnata leaves. Asian J. Cell Biol. 2017;12:20-7.
Keke CO, Nsofor WN, Kumabia FK, Iloabuchi GC, Ejiofor JC, Osuagwu OL. GCMS and FTIR analysis of ethanol and methanol leave extract of Urena lobata (Caesar weed) for bioactive phytochemical constituents. Journal of Drug Delivery and Therapeutics. 2023 Jan 15;13(1):99-115.
More K, Tayade S, Gawande P, Manik S, Shelke D. Antioxidant and antimicrobial potential of Canavalia gladiata (Jacq.) DC. leaves and seeds: GC-MS based metabolic profiling. Indian Journal of Natural Products and Resources (IJNPR)[Formerly Natural Product Radiance (NPR)]. 2022 Jul 26;13(2):163-9.
Jabeen N, Javaid A, Ahmed E. Antifungal activity and phytochemical profile of chloroform soluble fraction of Datura metel fruit. 2022. Pp 1085 – 1091.
Jacobson M, Ohinata K, Chambers DL, Jones WA, Fujimoto MS. Insect sex attractants. 13. Isolation, identification, and synthesis of sex pheromones of the male Mediterranean fruit fly. Journal of medicinal chemistry. 1973 Mar;16(3):248-51.
Banakar P, Jayaraj M. GC-MS analysis of bioactive compounds from ethanolic leaf extract of Waltheria indica Linn. and their pharmacological activities. Int. J. Pharm. Sci. Res. 2018 May 1;9(5):2005-10.
Banakar P, Jayaraj M. GC-MS analysis of bioactive compounds from ethanolic leaf extract of Waltheria indica Linn. and their pharmacological activities. Int. J. Pharm. Sci. Res. 2018 May 1;9(5):2005-10.
Sales-Campos H, Reis de Souza P, Crema Peghini B, Santana da Silva J, Ribeiro Cardoso C. An overview of the modulatory effects of oleic acid in health and disease. Mini reviews in medicinal chemistry. 2013 Feb 1;13(2):201-10.
Dilika F, Bremner PD, Meyer JJ. Antibacterial activity of linoleic and oleic acids isolated from Helichrysum pedunculatum: a plant used during circumcision rites. Fitoterapia. 2000 Aug 1;71(4):450-2.
Kamenetsky R, London Shafir I, Khassanov F, Kik C, Van Heusden AW, Vrielink-van Ginkel M, Burger-Meijer K, Auger J, Arnault I, Rabinowitch HD. Diversity in fertility potential and organo-sulphur compounds among garlics from Central Asia. Biodiversity & Conservation. 2005 Feb;14:281-95.
Petropoulos S, Di Gioia F, Ntatsi G. Vegetable organosulfur compounds and their health promoting effects. Current pharmaceutical design. 2017 May 1;23(19):2850-75.
Micová M, Bystrická J, Kovarovič J, Harangozo Ľ, Lidiková A. Content of bioactive compounds and antioxidant activity in garlic (Allium sativum L.). Acta agriculturae Slovenica. 2018 Dec 12;111(3):581-95.
Kumar N, Goel N. Phenolic acids: Natural versatile molecules with promising therapeutic applications. Biotechnology reports. 2019 Dec 1;24:e00370.
Gan J, Feng Y, He Z, Li X, Zhang H. Correlations between antioxidant activity and alkaloids and phenols of maca (Lepidium meyenii). Journal of Food Quality. 2017;2017(1):3185945.
Tiong SH, Looi CY, Hazni H, Arya A, Paydar M, Wong WF, Cheah SC, Mustafa MR, Awang K. Antidiabetic and antioxidant properties of alkaloids from Catharanthus roseus (L.) G. Don. Molecules. 2013 Aug 15;18(8):9770-84.
Silva AP, da Costa WA, Salazar M, do Nascimento BP, Pires FC. Commercial and therapeutic potential of plant-based fatty acids. IntechOpen. 2018 Nov 5;5:73-90.
Perumal Samy R, Sethi G, TK Chow V, G Stiles B. Plant-based hydrocarbon esters from Tragia involucrata possess antimicrobial and anti-inflammatory activities. Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious Disorders). 2013 Apr 1;13(2):141-53.
Al-Saraireh, Y. M., Youssef, A. M., Alsarayreh, A. Z., Al Hujran, T. A., Al-Sarayreh, S., Al-Shuneigat, J. M., & Alrawashdeh, H. M. (2021). Phytochemical and anti-cancer properties of Euphorbia hierosolymitana Boiss. crude extracts. J. Pharm. Pharmacogn. Res, 9(13-23).
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